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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c55dafe0d2fb6a976e248801c961bc0c78586bedb84390905a3df3bbb072c305' 
  AND token = 'sOI4sB0esfXY/q/sLV2412RWSGZAjrQ2z4yDkp5ZVGk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00055

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}