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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8a4408dc28a5d746eca6b5b1574e8fc4debc44b2ae5233ee6609335b29967319' 
  AND token = 'wU5dE01j+i/I0tdRnwv/X4kAbx+qWLaC7Wzir467Zbg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}