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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e0b3674446829043294a4d0798877988490c83b385cf967275e51d2fba230c61' 
  AND token = 'O360eL4agZGMY5XXJ2X6/qayNz+1mCAjO2khy/ARSFA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}