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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '65d8a6f8900707fcd2b78b7f347a143700f6b9c77e06f3dc9e627040cb8d0991' 
  AND token = 'EQeTOH0Km4l6+91zW9ug0IDcFvaBuJRh5a+AjbRagtM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}