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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '25cebb4ebf02f7408fa3c6d11e49d1e37c9b956117863ecd08de0229e2e9a2d8' 
  AND token = 'kRB8FxuKhVh+9EzasHLTU7gYs6F2PIk3+gEhUxmOVA0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}