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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e21bd31bac87166537a01905cbef5db6a194a8d3365f52cb3a0f93364aa15b72' 
  AND token = '+Ir3ik8eO0q59Km029h14rH0G2pDQTfj81lw3QG3FrQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}