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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b8180349c1a3cd4a583d63488f766661333183f366f74fcc1f959b4eba51de51' 
  AND token = 'h5VmyJARiyVvxOHJmcC+Q6tDHR6pfyPcGMHX0hF58HM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}