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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f44d9e48f1cf824e5269082b07450b254a1ad2a761ce273d96980c9a9a62765a' 
  AND token = 'GHLaS4Bc/TijN+/g82bnz7kvcs0y40ssrCrd7Cf4Fag=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}