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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c9d2e1d3622ce2f778fb89017c8e3d56e318f2561e7121a3936d16a162057621' 
  AND token = 'Z+0thGrFrH0wT38aPs3F5QixkAfiF2nc0DIHpNdJ5T8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}