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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2345fb7dc2a61f38bdd4bebe6ebd8d894819e4e0235b11cc5236669cf8b9fa0b' 
  AND token = 'EP4ss33MYzUdq+DOOAItHU1zEzpbXNaWNODu4qDu9ZU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}