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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '81b388b5fdd8191b72caaa337639a4bbbd966690509693be4a2f11bb450b5f30' 
  AND token = 'Cz+7BrC4AdXMZR0a592q6Ly6RdCiuI4o6Bt15xxVCiM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}