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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8af2c14e12d3571851bf5ec79a29c52d4fc7d799a29ce3a5c0b7ad59e016fbf7' 
  AND token = 'qy1U33lpig1uK9q/HMoS5D6+ZCalqQ3rWlNnlCts47c=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}