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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2e140075810c7ea6bdf1c8975543ee7a820af958685bb848d381d3352e0d9211' 
  AND token = 'Fxz0qPzsJYLDXS7RUAJwSmJkc+O5tS+4Uiwo/hUMavc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}