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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '45c39c88adbaa280a2c1d1648911fc2a2ceae7279200b18e555c6f6f1d83e4f5' 
  AND token = 'NVH8c5L+dv8+ey2mgnVKSmPIR2hAxnZFF4id24vxfJE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00042

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}