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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '249a1b00e3b0b86c51cde93ef27646d1ca30777f76bf1eaf77bc508ec3916a49' 
  AND token = 'UCk2egSL0hnuzafQZ3Yw2E3DPJ2eqgfRJUWIfDuEOL4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00045

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}