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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '53698f9d50a220fc0fa10a95502ab27e5b7ca2e1ea2996a39cc99ff8c570511f' 
  AND token = 'PUSrSiwPgHkgPlF09phs5uhsJqoAtB8j4T5Gf1YTxkU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}