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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5381ed93081e7abdf717f72d4b47d002621cd0280df9ee6be1c327cf21a8c3c7' 
  AND token = 'TudfbxUlr6zkqmPlIhs/T9wJ8ZgwroJeeRkBdaYlAZM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}