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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f5100e41358dc5b7842fb8f9aa8e89f1a2f9ae632217335fd28f9dd344301fd4' 
  AND token = 'b5rXKW1v+2TeRcWAcseO10Y26hzaV0r26jq4iTPhL/I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}