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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8f357574207fb54f9e6b2f9bcc589594a55db78bd232f0db51bb61d7af16ed94' 
  AND token = 'T4wzj3pej4Fn5yLlNYvxqk28QlT5xSpl7f0Ma5XwgoY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}