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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '648a48378692220477066708bab6bf4aafb0512aab7484260c67468586ee05fb' 
  AND token = 'wU8vePe49eJnyiLMyof83nJ7oqqVvGFZ8LI2M2Zp3PI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}