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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '461d4ca1fc633a2d5c8d77d8d9198d339c30ad4857a26175260f20e20aff9fc7' 
  AND token = 'rHGxXHLmN3ufMQ9a/PlyZtE4vqunPCfT/PiSCeDJ4gE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}