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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '187d6423948bf1bd13b48c93ac2de4eb5c8ae03c53f7cc0c7503e48fad7b8126' 
  AND token = 'jHEiDu3z2aMYpCYA0cBrOhrsGMttTj2zOCf8rBw27e0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}