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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '287991f65ef41cc0ab99c589d5a9874cdfd66c72857ef7e30794fc8df499f12c' 
  AND token = 'cOmvo+gjKWFUGuzKVjPZW1itrHhBjEBWrT9y1r8TtSk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}