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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43a081a2339eda7f001186b516ddf11bb13383eed2e69c9e1e50a73cddb76dcf' 
  AND token = 'Xk1F7RQIAsCWGmM4PiD9MCs+5Nd67taqkm8Apw/K7DE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}