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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '80e155c606e34780b22dcd1a9e6581eb47d8e862e40a20fd04af747dc04d4a5e' 
  AND token = 'uaY3e5aO3/qp2Y+AvtHbDXW/E9VeRwSL6V4h7zuXTUU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}