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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '46775c0300dc5cc80891a161bb088ecd34ccb927c0d61bd796f8da1b8c4ce685' 
  AND token = 'qNrQwM4PYGgPhn//c00PP9b+rDi+URm2TZm+8VqPTIU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}