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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b186d4647044fc3cf919b4cc81ddc703e641b7baa89feeb494b370e19a4b2ee4' 
  AND token = 'V+DhXJU1U3rIOYGUCxlI6C8qx2UR0zRl0VSZOweNwgs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}