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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c2f45718e50e500abcccbf69da87890387aafbbbfb337d6a0551cf35b4d180b8' 
  AND token = 'VhOk9I0DVQNwv3oxtmR/urmeeTuSeQFvBv99rcrgJ08=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}