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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '395bf82fb70c27306a422ffe69bf7937cb2acada6ba683c029dd77d31941ed03' 
  AND token = '4E+cxL46X6KmGH3KPdaZh0wLE68pyaXvMLEd6QRIvAU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}