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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c221f3cced98badc3f287a809824e25e9f9e169f2f7c57433a9c0203a1b56944' 
  AND token = 'VdZyZNGaMmJNzdbgiNiGlIyyNiN4CYxrvMY9iPF5XJ0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00047

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}