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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0378959951d5d2c2a8421d13b7febbd72f35497e0b5ec1a18e504bae0c7254cd' 
  AND token = 'rDV2JqTa1p2fDoDOGTXfECuFs/lTVvAjNOf5CyFUg2o=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00042

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}