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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22e8ad12f343a9b9bd2e2c314b166c33a0452b5afc60589a99648b6056b16950' 
  AND token = 'UQMAYXX8lkIlDm1HW3MbQ0tw+Bn2m4MW9l+JlOyTw5Q=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}