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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e080b90f7e3c3b488cb12524f7d9a44b891f9a1bbfff3991dcef985ac3f6549f' 
  AND token = 'BkB1Hg0Jlo/lTClaE0YJIQQxmnMg+ePo+rQyWXdJ524=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}