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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3b16e9a81ef637023bc95450fddaa3c29b2d18d6c4447661a39b3ad1b3d27368' 
  AND token = '1ipF5V+Pcbo2lDgs6UsooY0h+P8+mHq+1jGCzY10cQQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00041

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}