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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e18ae584e71e8dae3fc93a0e87d1a6fc2adb91c684ab69f3f3ff14d411841260' 
  AND token = '+2YuGqCoOhhETYEiTH6Dw91CYiZvROO3n6GTuqIlSC8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}