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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6ed1debcf92cfe36dccf832b49b25b6b26ac459f540440edf879de3dd57c5701' 
  AND token = 'QE1AJZSbZ5ETHiqSDjH5bAqdODy2xE2LXDfRjrLVzRE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00041

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}