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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ce8fa4d5d86592cb576a2a6bdbe35f3b61f9cbb55d6059f907469e8778013a1c' 
  AND token = 'V2RM+IIRA2WEtGzNTWdG7CQoXBs5n4zNSWE2cUygxYY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}