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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'aa4406580be736733c3d9a0449ad4f94e5d59d4b1f07b4f15133ecab3469cbbb' 
  AND token = 'Yw1lFgZmsoe1wGKUlGlikWHp7yqJMROWNF+gEML7nmI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}