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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c743048748a657b062bc5f21cc803285c6e8f371271a420b8a22896af71dd25d' 
  AND token = '7eB4E1Uuf5gTb7NRiio9Fa0PLDY0jrX6k+UbBC2yWAI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}