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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '65dd8a43112cd8d9a28b4065f84f060bee05b2b7b205d78b713ea71f11dcd6a1' 
  AND token = 'ek6Shgu2XScU6B3IYRW3Q5tmEjoPpAFZaAB2BmPhnUc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}