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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'be3fdb1c280c7a6a30c3e0843f9b8819d28eef666c7016541c10df32688a103f' 
  AND token = '497NhYCo9ZZ6zx8MdOALSc+kjNDc/6s4aM6ZNQpY3oA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}