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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21b1456f01c3e7982d1d616e9376561b967a720b1a88f116b90d5162518378a4' 
  AND token = 'DOhvz2Xqt9OZ4fm/rVe4pJOgTX3rdeAbVU7PTqv6o5c=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}