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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2b5a5469d3e94650b8adcb8259b14242bf9055b3e6971d777b250a34a0e95531' 
  AND token = '2bFgfxtPzZi+TkO1NGIidgxbgVuVMXONWWH4xZt4WKI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}