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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4ad7510f13d237fec41353e9bad14a2ac3956ab03ccda6ce343ce11fcb39dad1' 
  AND token = 'zBm7Rb3pYQDGx+3oL523PLIdhjHIPGI00DSDI7QC5Lg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}