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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '72e20610a20d80b1f288436bb6ad8849a335dd14bf7afe026cbe26c7280a7de6' 
  AND token = 'KCp9dlLIk5TVek476zO6PRFQOVIE7KXRYL/ggRciUZk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}