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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ed8bc2cc7886c5fc5f6675ece148457e120811a8d33f8caf6c3a4918e3675f35' 
  AND token = 'MXF0SpynpaAdOfzbg5zaVbGum+W/Cg4tTZwQLWDoYdE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00041

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}