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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1e1dc03d47aa58848c069f972d3de1f471ccff7ddcd32d1d4f9b9c9056e252c9' 
  AND token = 'nfSs3ruxR+dNj9Nj3CkFySTESD2Tg/GXxs7dhtoh/e0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}