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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e921c0b0af68f31b899030101d70f1cbb743fe2a5955b7de2476715a2e64aced' 
  AND token = 'S+NoZeEe5c5DdOxkMmg6Xv9llFZ5plWwuX0YxqtLHds=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}