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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd17c3f606f3c6cd7ce237b978d3da0315d825b56f8025da4e2c45016e5166c05' 
  AND token = 'zc1DnTDblE+UPG4pdtCZhXOx5PJVAEASB8BSoLnNpR8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}