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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5e3e195330cf46a10000f6287e0592588f58e31e7eb9fb502d49e50668196ab6' 
  AND token = '/Ydw4iSXHuQm8Uw6LBIVwf30sqAHIBK1SuY/CCObuvQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}